CSL ‐ DNA interactions, from thermodynamics to structure

Lipid bilayers: thermodynamics, structure, fluctuations, and interactions.

This article, adapted from our acceptance speech of the Avanti Award in Lipids at the 47th Biophysical Society meeting in San Antonio, 2003, summarizes over 30 years of research in the area of lipid bilayers. Beginning with a theoretical model of the phase transition (J.F.N.), we have proceeded experimentally using dilatometry and density centrifugation to study volume, differential scanning ca...

Structure, Thermodynamics and Energetics of Drug-DNA Interactions: Computer Modeling and Experiment

Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.

Notch signaling is a conserved pathway of communication between neighboring cells that results in cell fate specification, and CSL is the universal transcriptional effector of Notch signaling. The Notch intracellular domain translocates to the nucleus after proteolytic release upon Notch extracellular engagement, and there it displaces corepressors from DNA-bound CSL and recruits activators of ...

Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA

Notch signaling mediates communication between cells and is essential for proper embryonic patterning and development. CSL is a DNA binding transcription factor that regulates transcription of Notch target genes by interacting with coregulators. Transcriptional activation requires the displacement of corepressors from CSL by the intracellular portion of the receptor Notch (NotchIC) and the recr...

CSL-p53: From senescence to CAF activation.